• Login
    View Item 
    •   SMARTech Home
    • Undergraduate Research Opportunities Program (UROP)
    • Undergraduate Research Option Theses
    • View Item
    •   SMARTech Home
    • Undergraduate Research Opportunities Program (UROP)
    • Undergraduate Research Option Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Differentiation and Proliferation of Therapeutic T cells from umbilical cord blood derived cells

    Thumbnail
    View/Open
    HOLZWORTH-UNDERGRADUATERESEARCHOPTIONTHESIS-2022.pdf (1.626Mb)
    Date
    2022-05
    Author
    Holzworth, Peyton
    Metadata
    Show full item record
    Abstract
    Cancer is among the leading causes of death worldwide; in 2018, there were 18.1 million new cases and 9.5 million cancer-related deaths. Current methods, such as chemotherapy, have been used for decades and while it is a decent treatment, it is not feasible in the long run for consistent reference because of the effects of radiation and the growing resistance that cancer cells develop. As a result of cancer cells having mutations that can result in “hidden” receptors, making them undiscoverable by the body's T cells, immunotherapy has emerged as a new approach to cancer treatments. Adoptive cell therapies using chimeric antigen receptor (CAR) T cells, more specifically, have shown promise due to their ability to incorporate the receptors and antibodies necessary to discover the cancer cells despite mutated patterns. Umbilical Cord Blood (UCB) T cells are a new, up and coming technology that are obtained through derivation from umbilical cord blood. In this thesis, UCB T cells are combined with 3 variable expansion systems and cultured with and without transduction to determine proliferation rate, phenotypic qualities, and CAR expression to determine the capabilities of their usage as an allogeneic adoptive cell therapy.
    URI
    http://hdl.handle.net/1853/66760
    Collections
    • Department of Biomedical Engineering Undergraduate Research Option Theses [214]
    • Undergraduate Research Option Theses [862]

    Browse

    All of SMARTechCommunities & CollectionsDatesAuthorsTitlesSubjectsTypesThis CollectionDatesAuthorsTitlesSubjectsTypes

    My SMARTech

    Login

    Statistics

    View Usage StatisticsView Google Analytics Statistics
    facebook instagram twitter youtube
    • My Account
    • Contact us
    • Directory
    • Campus Map
    • Support/Give
    • Library Accessibility
      • About SMARTech
      • SMARTech Terms of Use
    Georgia Tech Library266 4th Street NW, Atlanta, GA 30332
    404.894.4500
    • Emergency Information
    • Legal and Privacy Information
    • Human Trafficking Notice
    • Accessibility
    • Accountability
    • Accreditation
    • Employment
    © 2020 Georgia Institute of Technology