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    Hsp90 and the Evolution of Novel Cellular Differentiation

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    CHENG-UNDERGRADUATERESEARCHOPTIONTHESIS-2022.pdf (410.5Kb)
    Date
    2022-05
    Author
    Cheng, Vivian
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    Abstract
    Cellular differentiation is a prerequisite for complex multicellular life, yet little is known about how it evolves de novo. Several mechanisms may explain how early multicellular organisms evolved to perform cell-specific roles. In this work, I explore the potential role of cellular aging in driving age-dependent differences that evolve to become co-opted for a novel role in cellular differentiation. Specifically, I am examining how, in the snowflake yeast model system of nascent multicellularity, the Hsp90 class chaperone proteins have evolved to act in a novel age-dependent manner, thus driving the emergence of adaptive differences in protein activity among cells.
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    http://hdl.handle.net/1853/66764
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    • School of Biology Undergraduate Research Option Theses [146]
    • Undergraduate Research Option Theses [862]

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