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dc.contributor.authorRangamani, Padminien_US
dc.date.accessioned2005-09-16T15:02:27Z
dc.date.available2005-09-16T15:02:27Z
dc.date.issued2005-06-01en_US
dc.identifier.urihttp://hdl.handle.net/1853/7140
dc.description.abstractCartilage tissue engineering is an emerging treatment option for osteoarthritis and trauma related joint injuries. A continuing challenge for cartilage tissue engineering is increasing construct extracellular matrix production and material properties. Shear stress and oxygen tension play an important role in tissue engineering of cartilage. In this select stimulatory conditions using combinations of shear stress and oxygen tension have been used to enhance the construct extracellular matrix deposition and material properties. Additionally, a perfusion concentric cylinder bioreactor has been developed to incorporate multiple fluid flow regimes through the construct. This thesis attempts to elucidate the effect of shear stress and biochemical conditions on cartilage development in vitro to provide functional tissue engineered constructs.en_US
dc.format.extent1395927 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectBioprocessingen_US
dc.subjectCartilage
dc.subjectTissue engineering
dc.subject.lcshShear flowen_US
dc.subject.lcshTissue engineeringen_US
dc.subject.lcshBiochemical engineeringen_US
dc.subject.lcshBioreactorsen_US
dc.subject.lcshCartilageen_US
dc.titleBioprocessing Conditions for Improving the Material Properties of Tissue Engineered Cartilageen_US
dc.typeThesisen_US
dc.description.degreeM.S.en_US
dc.contributor.departmentChemical Engineeringen_US
dc.description.advisorCommittee Chair: Wick, Timothy; Committee Member: Boyan, Barbara; Committee Member: Guldberg, Robert; Committee Member: Koros, William; Committee Member: Rousseau, Ronalden_US


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