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dc.contributor.authorPatz, Timothy Matthewen_US
dc.date.accessioned2006-01-18T22:11:38Z
dc.date.available2006-01-18T22:11:38Z
dc.date.issued2005-07-14en_US
dc.identifier.urihttp://hdl.handle.net/1853/7451
dc.description.abstractI have explored the use of the matrix assisted pulsed laser evaporation (MAPLE) and MAPLE direct write (MDW) to create thin films of biological materials. MAPLE is a novel physical vapor deposition technique used to deposit thin films of organic materials. The MAPLE process involves the laser desorption of a frozen dilute solution (1-5%) containing the material to be deposited. A focused laser pulse (~200 mJ/cm2) impacts the frozen target, which causes the solvent to preferentially absorb the laser energy and evaporate. The collective action of the evaporated solvent desorbs the polymeric solute material towards the receiving substrate placed parallel and opposite to the target. The bioresorbable polymer PDLLA and the anti-inflammatory pharmaceutical dexamethasone were processed using MAPLE, and characterized using Fourier transform infrared spectroscopy, atomic force microscopy and x-ray photoelectron spectroscopy. MDW is a CAD/CAM controlled direct writing process. The material to be transferred is immersed in a laser-absorbing matrix or solution and coated onto a target or support positioned microns to millimeters away from a receiving substrate. Using a UV microscope objective, a focused laser pulse is directed at the backside of the ribbon, so that the laser energy first interacts with the matrix at the ribbon/matrix interface. This energy is used to gently desorb the depositing material and matrix onto the receiving substrate. I have deposited neuroblasts within a three-dimensional extracellular matrix. These two laser processing techniques have enormous potential for functional medical device and tissue engineering applications.en_US
dc.format.extent860820 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectMAPLEen_US
dc.subjectMDW
dc.subject.lcshThin filmsen_US
dc.subject.lcshVapor-platingen_US
dc.subject.lcshBiomedical materialsen_US
dc.titleLaser Processing of Biological Materialsen_US
dc.typeThesisen_US
dc.description.degreeM.S.en_US
dc.contributor.departmentMaterials Science and Engineeringen_US
dc.description.advisorCommittee Chair: Roger J. Narayan; Committee Member: Barbara Boyan; Committee Member: Ravi Bellamkondaen_US


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