Mass-Sensitive Biochemical Microsensors

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Title: Mass-Sensitive Biochemical Microsensors
Author: Brand, Oliver
Abstract: A resonant microsensor platform based on disk-type microstructures vibrating in an in-plane resonance mode for chemical and biochemical sensing applications in gas and liquid environments is presented. Based on measured short-term frequency stabilities of 1.1 10^-8 in air and 2.3 10^-6 in water, mass detection limits in the low femtogram and sub-picogram, respectively, are achieved. In a biosensing application, biomolecules are immobilized on the resonator surface. Upon selective binding of analyte molecules (e.g. via antibody-antigen binding), the mass of the resonator is increased, resulting in a measurable decrease of its resonance frequency. The feasibility of liquid-phase biosensing using the disk resonators is demonstrated experimentally by detecting anti-beta-galactosidase antibody using covalently immobilized beta-galactosidase enzyme.
Description: Presented on October 10, 2008 from 11am-2pm at the Microelectronics Research Center building on the Georgia Tech campus This talk was part of the fall 2008 meeting of the NANOFANS Forum: Bridging Biology and Nanotechnology Runtime: 31:08 minutes
Type: Presentation
Date: 2008-10-10
Contributor: Georgia Institute of Technology. Microelectronics Research Center
Georgia Institute of Technology. School of Electrical and Computer Engineering
Publisher: Georgia Institute of Technology
Subject: Sensors
Biochemical microsensors

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