The Biology and Therapeutic Promise of Small RNAs

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Title: The Biology and Therapeutic Promise of Small RNAs
Author: Sharp, Phillip A.
Abstract: The discovery of the multiple roles of small RNAs in regulation of gene expression is a revolutionary advance in biology. MicroRNAs probably interact with mRNAs from half of all human genes. Overexpression of some microRNAs is associated with certain types of cancer while, more commonly, a reduction in microRNA levels is seen in tumors. Recent evidence suggests that the primary role of microRNAs might be to provide robustness or stability to systems. We have recently found that cytoplasmic subcellular localization of mRNAs and microRNAs is dependent upon formation of poly(ADP-ribose) and that microRNA repression is reduced under stress conditions.
Description: Presented by Phillip A. Sharp, PhD., Institute Professor at the Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology on October 2, 2009 11:00 am – 12:30 pm in the IBB Atrium on the Georgia Tech campus.
Type: Lecture
Date: 2009-10-02
Contributor: Georgia Institute of Technology. Institute for Bioengineering and Bioscience
Massachusetts Institute of Technology. Koch Institute for Integrative Cancer Research
Publisher: Georgia Institute of Technology
Subject: MicroRNAs
Small RNAs

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