Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1853/34013

Title: Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas
Author: Moreno, Carlos S. ; Matyunina, Lilya V. ; Dickerson, Erin B. ; Schubert, Nina ; Bowen, Nathan J. ; Logani, Sanjay ; Benigno, Benedict B. ; McDonald, John F.
Abstract: Gene expression profiles of malignant tumors surgically removed from ovarian cancer patients pre-treated with chemotherapy (neo-adjuvant) prior to surgery group into two distinct clusters. One group clusters with carcinomas from patients not pretreated with chemotherapy prior to surgery (C-L), while the other clusters with non-malignant adenomas (A-L). We show here that although the C-L cluster is preferentially associated with p53 loss-of-function (LOF) mutations, the C-L cluster cancer patients display a more favorable clinical response to chemotherapy as evidenced by enhanced long-term survivorships. Our results support a model whereby p53 mediated cell-cycle-arrest/DNA repair serves as a barrier to optimal chemotherapeutic treatment of ovarian and perhaps other carcinomas and suggest that inhibition of p53 during chemotherapy may enhance clinical outcome.
Description: © 2007 Moreno et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. DOI: 10.1371/journal.pone.0000441
Type: Article
URI: http://hdl.handle.net/1853/34013
ISSN: 1932-6203
Citation: Carlos S. Moreno, Lilya Matyunina, Erin B. Dickerson, Nina Schubert, Nathan J. Bowen, Sanjay Logani, Benedict B. Benigno, and John F., "Evidence that p53-Mediated Cell-Cycle-Arrest Inhibits Chemotherapeutic Treatment of Ovarian Carcinomas," PLoS ONE 2(5) e441
Date: 2007-05-17
Contributor: Emory University. Dept. of Pathology and Laboratory Medicine
Winship Cancer Institute of Emory University
Georgia Institute of Technology. School of Biology
Georgia Institute of Technology. Ovarian Cancer Institute
Publisher: Georgia Institute of Technology
Public Library of Science
Subject: Ovarian cancer
P53 gene
Inhibition of p53 during chemotherapy
Long-term survival

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