Functional molecular imaging in the brain

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Title: Functional molecular imaging in the brain
Author: Jasanoff, Alan
Abstract: Functional magnetic resonance imaging (fMRI) with contrast agents sensitive to neural activity could have great impact in neuroscience by combining noninvasive whole-brain coverage with molecular-level specificity for neuronal events. My laboratory is developing molecular fMRI approaches based on molecular sensors we have designed to detect intra- and extracellular signalling events in the nervous system. Our sensors are built on a variety of chemical platforms, ranging from small molecules to nanoparticles. Protein-based contrast agents are of particular interest to us because of the possibility of gene-based brain delivery strategies and the availability of powerful protein engineering techniques. Here we describe molecular engineering of several MRI sensors for neural activity, as well as the first efforts in our laboratory to perform functional neuroimaging with molecular specificity in living brains.
Description: Alan Jasanoff, Ph.D. of the Massachusetts Institute of Technology presented a lecture on Feb. 24, 2011 from 11:00 am - 12:00 pm in the IBB building, room 1128. Runtime:64:11 minutes.
Type: Lecture
Date: 2011-02-24
Contributor: Georgia Institute of Technology. Institute for Bioengineering and Bioscience
Massachusetts Institute of Technology
Publisher: Georgia Institute of Technology
Subject: Functional molecular imaging

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