Small RNA Regulation of the Quorum Sensing Response in the Bacterial Pathogen Vibrio Cholerae

Show simple item record Hammer, Brian 2011-06-27T20:29:33Z 2011-06-27T20:29:33Z 2011-06-14
dc.description Presented on June 14, 2011 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering & Bioscience (IBB), room 1128, Georgia Tech. en_US
dc.description Runtime: 53:51 minutes
dc.description.abstract Vibrio cholerae, the waterborne bacterium responsible for the deadly disease cholera, is both a transient human pathogen and a ubiquitous inhabitant of marine environments. The pathogenesis and ecology of this deadly microbe are the focus of research in the Hammer lab. V. cholerae has become a model organism to understand a process of microbial cell-cell communication called quorum sensing, which allows bacterial groups to act in unison by synchronizing gene expression in response to population density. V. cholerae, and many other Vibrio species, achieves quorum sensing by producing and then responding to chemical signal molecules, called autoinducers, which control the production of multiple regulatory small RNAs. In V. cholerae, these non-coding sRNAs are predicted to base-pair with, and alter the translation of, several mRNAs encoding protein regulators that alter the expression of >100 genes. Many of the quorum-sensing regulated genes (such as the cholera toxin and attachment factors) are critical for host colonization, while others (such as genes involved in horizontal gene transfer) are important in marine ecosystems. We are currently using genetic, biochemical, and computational methods to define the mechanism of sRNA control and the role of V. cholerae quorum sensing in clinical and environmental settings. en_US
dc.format.extent 53:51 minutes
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.relation.ispartofseries Petit Institute Breakfast Club Seminar Series
dc.subject Bacterial genetics en_US
dc.subject Quorum sensing en_US
dc.subject Signal transduction en_US
dc.subject sRNAs en_US
dc.subject Vibrio cholerae en_US
dc.title Small RNA Regulation of the Quorum Sensing Response in the Bacterial Pathogen Vibrio Cholerae en_US
dc.type Lecture en_US
dc.type Video en_US
dc.contributor.corporatename Georgia Institute of Technology. Institute for Bioengineering and Bioscience
dc.contributor.corporatename Georgia Institute of Technology. School of Biology

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