Effects of ectopic expression of caudal during Drosophila development

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Title: Effects of ectopic expression of caudal during Drosophila development
Author: Mlodzik, Marek ; Gibson, Greg ; Gehring, Walter J.
Abstract: The effects of heat-shock-induced ectopic expression of the homeobox gene caudal (cad) at all stages of Drosophila development have been examined. Presence of cad protein (CAD) at the anterior end of cellular blastoderm embryos was found to disrupt head development and •segmentation, due to alteration of the expression of segmentation genes such asfushi tarazu and engrailed, as well as repression of head-determining genes such as Deformed. These results support the conclusion that, while CAD is probably required to activate transcription of fushi tarazu in the posterior half of the embryo, it should not be expressed in the anterior half prior to gastrulation, and thus suggest a role for the CAD gradient. Ectopic expression of CAD at later stages of development has no obvious effects on embryogenesis or imaginal disc development, suggesting that the homeotic genes of the Antennapedia and Bithorax Complexes are almost completely epistatic to caudal.
Description: © The Company of Biologists Limited 1990 The definitive version of this article is available at: http://dev.biologists.org/content/109/2/271.abstract
Type: Article
URI: http://hdl.handle.net/1853/41848
ISSN: 0950-1991
Citation: Mlodzik, M., G. Gibson, and W.J. Gehring (1990) Effects of ectopic expression of caudal during Drosophila development. Development 109:271-277.
Date: 1990-06-01
Contributor: Universität Basel. Biozentrum
Howard Hughes Medical Institute
Stanford University. Dept. of Developmental Biology
Publisher: Georgia Institute of Technology
Company of Biologists
Subject: Caudal
Fushi tarazu
Ectopic expression
Drosophila development
Segmentation

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